What are optimal days to defoliate or deleaf in flower or bloom?

We typically will defoliate at days 1, 21 and 42 of bloom and clean up the bottoms between days 1-14 depending on canopy density. However there are cases when you can clean them up throughout the first 21 days of bloom if the canopy is very dense and you want to allow light and air flow, some even do a light clean up every few days of the larger lower fan leaves usually showing purple stems.